The ECM, composed of proteoglycans, collagen, and minerals, is essential for maintaining the biomechanical properties of articular cartilage
Animal experiments confirmed that dural injection of bone marrow mesenchymal stem cell-derived exosomes miR-367-3p significantly reduced the expression of EZH2 in spinal cord tissues of EAE mice, increased the expression of SLC7A11, GPX4, GSH, and SOD, decreased the levels of Fe 2+ and MDA, inhibited spinal cord iron deposition, ferroptosis, and inflammation, and alleviated spinal cord injury ( 2+ and MDA levels, while reducing GSH, NRF2, and GPX4 expression, as well as iron reactive element binding protein 2 (IREB2) in optic nerve tissue
Their function is to regenerate all aged or injured cells in the body, build and retain muscle, burn fat for fuel, repair DNA and RNA, fight infections, help support healthy blood sugar and optimize brain function
10.1038/s41574-023-00833-4 46 ForslundK.HildebrandF.NielsenT.FalonyG.Le ChatelierE.SunagawaS.et al (2015)
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